A father, Hunter Isth, is rocked by a tragic accident in his life. He flees town and is no longer seen. Partying teenagers fall victim to a town lunatic. Throughout the years the stories become urban legends and more than likely, myths. In present day we meet Jenn, a tough and beautiful girl, who has just been released from an extensive stay at the hospital. When her parents bring her home she barely has time to rest as her friends come over and drag her out camping for the weekend. Seven friends venture out to the woods but as each friend starts to disappear one by one they each try to survive the wrath of a true mad man.

Will's best friend and roommate Belcher, (Ryan Dunn) a party bum slacker, returns from the dead as a cocky, mischievous, and perverted ghost. He soon discovers his cousin, Krista, has shacked up and moved in with his best friend, Will. Belcher will do anything and everything to destroy this relationship and get his prank buddy back.

A military weapons manufacturer creates a chemical weapon that causes victims to become blood-lusting killers. A lab accident causes the building to go into lock-down and the employees are trapped inside with the crazed killers.